VEGF-A enhances the cytotoxic function of CD4(+) cytotoxic T cells via the VEGF-receptor 1/VEGF-receptor 2/AKT/mTOR pathway

BACKGROUND: CD4(+) cytotoxic T cells (CD4 CTLs) are CD4(+) T cells with major histocompatibility complex-II-restricted cytotoxic function. Under pathologic conditions, CD4 CTLs hasten the development of autoimmune disease or viral infection by enhancing cytotoxicity. However, the regulators of the c...

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Detalles Bibliográficos
Autores principales: Chen, Ziyi, Zhang, Meng, Liu, Yufeng, Chen, Zhe, Wang, Ling, Wang, Wenjuan, Wang, Jincheng, He, Mingqian, Shi, Bingyin, Wang, Yue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9896805/
https://www.ncbi.nlm.nih.gov/pubmed/36737819
http://dx.doi.org/10.1186/s12967-023-03926-w

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