Tofacitinib reduces acute lung injury and improves survival in a rat model of sepsis by inhibiting the JAK-STAT/NF-κB pathway

Acute lung injury is a major cause of death in sepsis. Tofacitinib (TOFA), a JAK inhibitor, has anti-inflammatory activity in autoimmune diseases, but its role in acute lung injury in sepsis remains unclear. The purpose of this study is to establish a septic rat model by cecal ligation and perforati...

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Detalles Bibliográficos
Autores principales: Zhang, Xinxin, Wang, Xingsheng, Sun, Li, Gao, Guangsheng, Li, Yun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9896809/
https://www.ncbi.nlm.nih.gov/pubmed/36737780
http://dx.doi.org/10.1186/s12950-023-00332-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9896809/
https://www.ncbi.nlm.nih.gov/pubmed/36737780
http://dx.doi.org/10.1186/s12950-023-00332-3

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