Mechanisms of phase-separation-mediated cGAS activation revealed by dcFCCS

Cyclic GMP–AMP synthase (cGAS), as a DNA sensor, plays an important role in cGAS–STING pathway, which further induces expression of type I interferon as the innate immune response. Previous studies reported that liquid–liquid phase separation (LLPS) driven by cGAS and long DNA is essential to promot...

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Detalles Bibliográficos
Autores principales: Yao, Yirong, Wang, Wenjuan, Chen, Chunlai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Physical Sciences and Engineering
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9896928/
https://www.ncbi.nlm.nih.gov/pubmed/36741445
http://dx.doi.org/10.1093/pnasnexus/pgac109

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9896928/
https://www.ncbi.nlm.nih.gov/pubmed/36741445
http://dx.doi.org/10.1093/pnasnexus/pgac109

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