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Mechanisms of phase-separation-mediated cGAS activation revealed by dcFCCS
Cyclic GMP–AMP synthase (cGAS), as a DNA sensor, plays an important role in cGAS–STING pathway, which further induces expression of type I interferon as the innate immune response. Previous studies reported that liquid–liquid phase separation (LLPS) driven by cGAS and long DNA is essential to promot...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9896928/ https://www.ncbi.nlm.nih.gov/pubmed/36741445 http://dx.doi.org/10.1093/pnasnexus/pgac109 |