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Mechanisms of phase-separation-mediated cGAS activation revealed by dcFCCS

Cyclic GMP–AMP synthase (cGAS), as a DNA sensor, plays an important role in cGAS–STING pathway, which further induces expression of type I interferon as the innate immune response. Previous studies reported that liquid–liquid phase separation (LLPS) driven by cGAS and long DNA is essential to promot...

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Detalles Bibliográficos
Autores principales:	Yao, Yirong, Wang, Wenjuan, Chen, Chunlai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Physical Sciences and Engineering
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9896928/ https://www.ncbi.nlm.nih.gov/pubmed/36741445 http://dx.doi.org/10.1093/pnasnexus/pgac109

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