Structure-based design of selective, orally available salt-inducible kinase inhibitors that stimulate bone formation in mice

Osteoporosis is a major public health problem. Currently, there are no orally available therapies that increase bone formation. Intermittent parathyroid hormone (PTH) stimulates bone formation through a signal transduction pathway that involves inhibition of salt-inducible kinase isoforms 2 and 3 (S...

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Detalles Bibliográficos
Autores principales: Sato, Tadatoshi, Andrade, Christian D. Castro, Yoon, Sung-Hee, Zhao, Yingshe, Greenlee, William J., Weber, Patricia C., Viswanathan, Usha, Kulp, John, Brooks, Daniel J., Demay, Marie B., Bouxsein, Mary L., Mitlak, Bruce, Lanske, Beate, Wein, Marc N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9897432/
https://www.ncbi.nlm.nih.gov/pubmed/36472957
http://dx.doi.org/10.1073/pnas.2214396119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9897432/
https://www.ncbi.nlm.nih.gov/pubmed/36472957
http://dx.doi.org/10.1073/pnas.2214396119

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