Cargando…

Structure-based design of selective, orally available salt-inducible kinase inhibitors that stimulate bone formation in mice

Osteoporosis is a major public health problem. Currently, there are no orally available therapies that increase bone formation. Intermittent parathyroid hormone (PTH) stimulates bone formation through a signal transduction pathway that involves inhibition of salt-inducible kinase isoforms 2 and 3 (S...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sato, Tadatoshi, Andrade, Christian D. Castro, Yoon, Sung-Hee, Zhao, Yingshe, Greenlee, William J., Weber, Patricia C., Viswanathan, Usha, Kulp, John, Brooks, Daniel J., Demay, Marie B., Bouxsein, Mary L., Mitlak, Bruce, Lanske, Beate, Wein, Marc N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2022
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9897432/ https://www.ncbi.nlm.nih.gov/pubmed/36472957 http://dx.doi.org/10.1073/pnas.2214396119

Ejemplares similares

Partial prevention of glucocorticoid-induced osteocyte deterioration in young male mice with osteocrin gene therapy
por: Mazur, Courtney M., et al.
Publicado: (2022)

Dual targeting of salt inducible kinases and CSF1R uncouples bone formation and bone resorption
por: Tang, Cheng-Chia, et al.
Publicado: (2021)

OR03-2 Different Effects of Abaloparatide and h-PTH(1-34) on Osteoclastogenesis and Bone Resorption
por: Arlt, Heike, et al.
Publicado: (2019)

A parathyroid hormone/salt-inducible kinase signaling axis controls renal vitamin D activation and organismal calcium homeostasis
por: Yoon, Sung-Hee, et al.
Publicado: (2023)

Effects of abaloparatide and teriparatide on bone resorption and bone formation in female mice()
por: Arlt, Heike, et al.
Publicado: (2020)

A FAK/HDAC5 signaling axis controls osteocyte mechanotransduction
por: Sato, Tadatoshi, et al.
Publicado: (2020)

SUN-335 Abaloparatide Prevents Unloading-Induced Bone Loss in Adult Rats
por: Teguh, Dian A, et al.
Publicado: (2020)

Abaloparatide increases bone mineral density and bone strength in ovariectomized rabbits with glucocorticoid-induced osteopenia
por: Chandler, H., et al.
Publicado: (2019)

Deletion of PTH Rescues Skeletal Abnormalities and High Osteopontin Levels in Klotho (−/−) Mice
por: Yuan, Quan, et al.
Publicado: (2012)

OR29-01 Deleting Salt Inducible Kinases In Osteoprogenitor Cells Increases Trabecular Bone
por: Papaioannou, Garyfallia, et al.
Publicado: (2023)

Comparative study in estrogen-depleted mice identifies skeletal and osteocyte transcriptomic responses to abaloparatide and teriparatide
por: Lv, Zhengtao, et al.
Publicado: (2023)

Comparable Initial Engagement of Intracellular Signaling Pathways by Parathyroid Hormone Receptor Ligands Teriparatide, Abaloparatide, and Long‐Acting PTH
por: Sato, Tadatoshi, et al.
Publicado: (2021)

Parathyroid-Specific Deletion of Klotho Unravels a Novel Calcineurin-Dependent FGF23 Signaling Pathway That Regulates PTH Secretion
por: Olauson, Hannes, et al.
Publicado: (2013)

Iodisation of Salt in Slovenia: Increased Availability of Non-Iodised Salt in the Food Supply
por: Žmitek, Katja, et al.
Publicado: (2016)

Availability, Formulation, Labeling, and Price of Low-sodium Salt Worldwide: Environmental Scan
por: Yin, Xuejun, et al.
Publicado: (2021)

IN VITRO AVAILABILITY OF CHLORAMPHENICOL IN THE PRESENCE OF CADMIUM AND LEAD SALTS
por: Musa, A., et al.
Publicado: (2010)

An Analysis of the Mineral Composition of Pink Salt Available in Australia
por: Fayet-Moore, Flavia, et al.
Publicado: (2020)

Short-term changes in air humidity and water availability weakly constrain thermoregulation in a dry-skinned ectotherm
por: Le Galliard, Jean-François, et al.
Publicado: (2021)

Assessment of the household availability of oral rehydration salt in rural Botswana
por: Jammalamadugu, Swetha Bindu, et al.
Publicado: (2013)

Nuts and bolts of the salt-inducible kinases (SIKs)
por: Darling, Nicola J., et al.
Publicado: (2021)

Validation of the Surrogate Threshold Effect for Change in Bone Mineral Density as a Surrogate Endpoint for Fracture Outcomes: The FNIH‐ASBMR SABRE Project
por: Eastell, Richard, et al.
Publicado: (2021)

Salt Preference and Ability to Discriminate between Salt Content of Two Commercially Available Products of Australian Primary Schoolchildren
por: West, Madeline, et al.
Publicado: (2019)

A Survey on Salt Content Labeling of the Processed Food Available in Malaysia
por: Haron, Hasnah, et al.
Publicado: (2020)

Investigation of an efficient multi-modal convolutional neural network for multiple sclerosis lesion detection
por: Raab, Florian, et al.
Publicado: (2023)

Salt tolerance mechanisms in Salt Tolerant Grasses (STGs) and their prospects in cereal crop improvement
por: Roy, Swarnendu, et al.
Publicado: (2014)

A Constrained ICA-EMD Model for Group Level fMRI Analysis
por: Wein, Simon, et al.
Publicado: (2020)

Roles of salt-inducible kinases in cancer (Review)
por: Feng, Shenghui, et al.
Publicado: (2023)

Inhibition of CIN85-Mediated Invasion by a Novel SH3 Domain Binding Motif in the Lysyl Oxidase Propeptide
por: Sato, Seiichi, et al.
Publicado: (2013)

A salt-induced kinase is required for the metabolic regulation of sleep
por: Grubbs, Jeremy J., et al.
Publicado: (2020)

Should both iodised and non-iodised salt be made available in Chinese cities? A cross-sectional survey
por: Yu, J, et al.
Publicado: (2014)

Fast and easy synthesis of the non-commercially available standard isobutyl monophosphate (ammonium salt)
por: Escobedo-Hinojosa, Wendy, et al.
Publicado: (2021)

Iodine Availability through Iodized Salt in Portugal: 2010–2021 Sales Evolution and Distribution
por: Machado, Sarai Isabel, et al.
Publicado: (2023)

Salt inducible kinases 2 and 3 are required for thymic T cell development
por: Nefla, Meriam, et al.
Publicado: (2021)

Sleep quality in children: questionnaires available in Brazil
por: Cavalheiro, Maria Gabriela, et al.
Publicado: (2017)

The multiple roles of salt-inducible kinases in regulating physiology
por: Jagannath, Aarti, et al.
Publicado: (2023)

Forecasting brain activity based on models of spatiotemporal brain dynamics: A comparison of graph neural network architectures
por: Wein, S., et al.
Publicado: (2022)

Lack of orientation specific adaptation to vertically oriented Glass patterns in human visual cortex: an fMRI adaptation investigation
por: Pavan, Andrea, et al.
Publicado: (2023)

OR03-1 The Effect of Abaloparatide on Bone Mineral Density and Fracture Incidence in Postmenopausal Women with Osteoporosis and Osteoarthritis
por: Lane, Nancy, et al.
Publicado: (2019)

Effect of Abaloparatide vs Alendronate on Fracture Risk Reduction in Postmenopausal Women With Osteoporosis
por: Leder, Benjamin Z, et al.
Publicado: (2019)

Availability of adequately iodized salt at household level in Dessie and Combolcha Towns, South Wollo, Ethiopia
por: Mekonnen, Tefera Chane, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_2e4uakis7i86fek4nfrviu068b