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A structural mechanism of nuclear receptor biased agonism

Efforts to decrease the adverse effects of nuclear receptor (NR) drugs have yielded experimental agonists that produce better outcomes in mice. Some of these agonists have been shown to cause different, not just less intense, on-target transcriptomic effects; however, a structural explanation for su...

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Detalles Bibliográficos
Autores principales: Nemetchek, Michelle D., Chrisman, Ian M., Rayl, Mariah L., Voss, Andrew H., Hughes, Travis S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9897460/
https://www.ncbi.nlm.nih.gov/pubmed/36469765
http://dx.doi.org/10.1073/pnas.2215333119