Cargando…

Biophysical characterization of calcium-binding and modulatory-domain dynamics in a pentameric ligand-gated ion channel

Pentameric ligand-gated ion channels (pLGICs) perform electrochemical signal transduction in organisms ranging from bacteria to humans. Among the prokaryotic pLGICs, there is architectural diversity involving N-terminal domains (NTDs) not found in eukaryotic relatives, exemplified by the calcium-sen...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lycksell, Marie, Rovšnik, Urška, Hanke, Anton, Martel, Anne, Howard, Rebecca J., Lindahl, Erik
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2022
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9897478/ https://www.ncbi.nlm.nih.gov/pubmed/36480474 http://dx.doi.org/10.1073/pnas.2210669119

Ejemplares similares

Probing solution structure of the pentameric ligand-gated ion channel GLIC by small-angle neutron scattering
por: Lycksell, Marie, et al.
Publicado: (2021)

Dynamic closed states of a ligand-gated ion channel captured by cryo-EM and simulations
por: Rovšnik, Urška, et al.
Publicado: (2021)

Markov state models of proton- and pore-dependent activation in a pentameric ligand-gated ion channel
por: Bergh, Cathrine, et al.
Publicado: (2021)

Ligand Activation of the Prokaryotic Pentameric Ligand-Gated Ion Channel ELIC
por: Zimmermann, Iwan, et al.
Publicado: (2011)

Signal Transduction Pathways in the Pentameric Ligand-Gated Ion Channels
por: Mowrey, David, et al.
Publicado: (2013)

Signal Transduction at the Domain Interface of Prokaryotic Pentameric Ligand-Gated Ion Channels
por: Bertozzi, Carlo, et al.
Publicado: (2016)

Regulation of a pentameric ligand-gated ion channel by a semiconserved cationic lipid-binding site
por: Sridhar, Akshay, et al.
Publicado: (2021)

Structural basis for ion permeation mechanism in pentameric ligand-gated ion channels
por: Sauguet, Ludovic, et al.
Publicado: (2013)

Evolution of Pentameric Ligand-Gated Ion Channels: Pro-Loop Receptors
por: Jaiteh, Mariama, et al.
Publicado: (2016)

Chasing the open-state structure of pentameric ligand-gated ion channels
por: Gonzalez-Gutierrez, Giovanni, et al.
Publicado: (2017)

Molecular Simulations of Hydrophobic Gating of Pentameric Ligand Gated Ion Channels: Insights into Water and Ions
por: Rao, Shanlin, et al.
Publicado: (2021)

Correction: Signal Transduction at the Domain Interface of Prokaryotic Pentameric Ligand-Gated Ion Channels
Publicado: (2016)

Molecular Mingling: Multimodal Predictions of Ligand Promiscuity in Pentameric Ligand-Gated Ion Channels
por: Koniuszewski, Filip, et al.
Publicado: (2022)

Inhibition of the Prokaryotic Pentameric Ligand-Gated Ion Channel ELIC by Divalent Cations
por: Zimmermann, Iwan, et al.
Publicado: (2012)

Allosteric regulation of pentameric ligand-gated ion channels: An emerging mechanistic perspective
por: Taly, Antoine, et al.
Publicado: (2014)

Pentameric Ligand-Gated Ion Channels as Pharmacological Targets Against Chronic Pain
por: Lara, César O., et al.
Publicado: (2020)

Site-Directed Spin Labeling Reveals Pentameric Ligand-Gated Ion Channel Gating Motions
por: Dellisanti, Cosma D., et al.
Publicado: (2013)

Structural Basis for Xenon Inhibition in a Cationic Pentameric Ligand-Gated Ion Channel
por: Sauguet, Ludovic, et al.
Publicado: (2016)

Molecular basis for convergent evolution of glutamate recognition by pentameric ligand-gated ion channels
por: Lynagh, Timothy, et al.
Publicado: (2015)

Recent Insight into Lipid Binding and Lipid Modulation of Pentameric Ligand-Gated Ion Channels
por: Ananchenko, Anna, et al.
Publicado: (2022)

Origin of acetylcholine antagonism in ELIC, a bacterial pentameric ligand-gated ion channel
por: Slobodyanyuk, Mykhaylo, et al.
Publicado: (2022)

Allosteric potentiation of a ligand-gated ion channel is mediated by access to a deep membrane-facing cavity
por: Heusser, Stephanie A., et al.
Publicado: (2018)

Un-gating and allosteric modulation of a pentameric ligand-gated ion channel captured by molecular dynamics
por: Martin, Nicolas E, et al.
Publicado: (2017)

Pentameric ligand-gated ion channels exhibit distinct transmembrane domain archetypes for folding/expression and function
por: Therien, J. P. Daniel, et al.
Publicado: (2017)

Druggable Lipid Binding Sites in Pentameric Ligand-Gated Ion Channels and Transient Receptor Potential Channels
por: Cheng, Wayland W. L., et al.
Publicado: (2022)

Structure of the pentameric ligand-gated ion channel ELIC cocrystallized with its competitive antagonist acetylcholine
por: Pan, Jianjun, et al.
Publicado: (2012)

Trapping of ivermectin by a pentameric ligand-gated ion channel upon open-to-closed isomerization
por: Degani-Katzav, Nurit, et al.
Publicado: (2017)

Macroscopic Kinetics of Pentameric Ligand Gated Ion Channels: Comparisons between Two Prokaryotic Channels and One Eukaryotic Channel
por: Laha, Kurt T., et al.
Publicado: (2013)

Multisite Binding of a General Anesthetic to the Prokaryotic Pentameric Erwinia chrysanthemi Ligand-gated Ion Channel (ELIC)
por: Spurny, Radovan, et al.
Publicado: (2013)

Direct Pore Binding as a Mechanism for Isoflurane Inhibition of the Pentameric Ligand-gated Ion Channel ELIC
por: Chen, Qiang, et al.
Publicado: (2015)

The atypical cation-conduction and gating properties of ELIC underscore the marked functional versatility of the pentameric ligand-gated ion-channel fold
por: Gonzalez-Gutierrez, Giovanni, et al.
Publicado: (2015)

Common Internal Allosteric Network Links Anesthetic Binding Sites in a Pentameric Ligand-Gated Ion Channel
por: Joseph, Thomas T., et al.
Publicado: (2016)

State-dependent protein-lipid interactions of a pentameric ligand-gated ion channel in a neuronal membrane
por: Dämgen, Marc A., et al.
Publicado: (2021)

Open-channel structure of a pentameric ligand-gated ion channel reveals a mechanism of leaflet-specific phospholipid modulation
por: Petroff, John T., et al.
Publicado: (2022)

Decrypting the Sequence of Structural Events during the Gating Transition of Pentameric Ligand-Gated Ion Channels Based on an Interpolated Elastic Network Model
por: Zheng, Wenjun, et al.
Publicado: (2011)

A chimeric prokaryotic pentameric ligand–gated channel reveals distinct pathways of activation
por: Schmandt, Nicolaus, et al.
Publicado: (2015)

Structural evidence for the binding of monocarboxylates and dicarboxylates at pharmacologically relevant extracellular sites of a pentameric ligand-gated ion channel
por: Fourati, Zaineb, et al.
Publicado: (2020)

Insect RDL Receptor Models for Virtual Screening: Impact of the Template Conformational State in Pentameric Ligand-Gated Ion Channels
por: Felsztyna, Iván, et al.
Publicado: (2022)

Polyunsaturated fatty acids inhibit a pentameric ligand-gated ion channel through one of two binding sites
por: Dietzen, Noah M, et al.
Publicado: (2022)

Full mutational mapping of titratable residues helps to identify proton-sensors involved in the control of channel gating in the Gloeobacter violaceus pentameric ligand-gated ion channel
por: Nemecz, Ákos, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_63937ejl9gt3uaoe7moidnppr6