Antibody accessibility determines location of spike surface mutations in SARS-CoV-2 variants

The steady emergence of SARS-CoV-2 variants gives us a real-time view of the interplay between viral evolution and the host immune defense. The spike protein of SARS-CoV-2 is the primary target of antibodies. Here, we show that steric accessibility to antibodies provides a strong predictor of mutati...

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Detalles Bibliográficos
Autores principales: von Bülow, Sören, Sikora, Mateusz, Blanc, Florian E. C., Covino, Roberto, Hummer, Gerhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9897577/
https://www.ncbi.nlm.nih.gov/pubmed/36693110
http://dx.doi.org/10.1371/journal.pcbi.1010822

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9897577/
https://www.ncbi.nlm.nih.gov/pubmed/36693110
http://dx.doi.org/10.1371/journal.pcbi.1010822

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