Cytidine deaminases catalyze the conversion of N(S,O)(4)-substituted pyrimidine nucleosides

Cytidine deaminases (CDAs) catalyze the hydrolytic deamination of cytidine and 2′-deoxycytidine to uridine and 2′-deoxyuridine. Here, we report that prokaryotic homo-tetrameric CDAs catalyze the nucleophilic substitution at the fourth position of N(4)-acyl-cytidines, N(4)-alkyl-cytidines, and N(4)-a...

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Detalles Bibliográficos
Autores principales: Urbelienė, Nina, Tiškus, Matas, Tamulaitienė, Giedrė, Gasparavičiūtė, Renata, Lapinskaitė, Ringailė, Jauniškis, Vykintas, Sūdžius, Jurgis, Meškienė, Rita, Tauraitė, Daiva, Skrodenytė, Emilija, Urbelis, Gintaras, Vaitekūnas, Justas, Meškys, Rolandas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9897663/
https://www.ncbi.nlm.nih.gov/pubmed/36735785
http://dx.doi.org/10.1126/sciadv.ade4361

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9897663/
https://www.ncbi.nlm.nih.gov/pubmed/36735785
http://dx.doi.org/10.1126/sciadv.ade4361

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