Identification of procathepsin L (pCTS-L)–neutralizing monoclonal antibodies to treat potentially lethal sepsis

Antibody-based strategies have been attempted to antagonize early cytokines of sepsis, but not yet been tried to target inducible late-acting mediators. Here, we report that the expression and secretion of procathepsin-L (pCTS-L) was induced by serum amyloid A (SAA) in innate immune cells, contribut...

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Detalles Bibliográficos
Autores principales: Zhu, Cassie Shu, Qiang, Xiaoling, Chen, Weiqiang, Li, Jianhua, Lan, Xiqian, Yang, Huan, Gong, Jonathan, Becker, Lance, Wang, Ping, Tracey, Kevin J., Wang, Haichao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9897667/
https://www.ncbi.nlm.nih.gov/pubmed/36735789
http://dx.doi.org/10.1126/sciadv.adf4313

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9897667/
https://www.ncbi.nlm.nih.gov/pubmed/36735789
http://dx.doi.org/10.1126/sciadv.adf4313

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