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Topological screen identifies hundreds of Cp190- and CTCF-dependent Drosophila chromatin insulator elements

Drosophila insulators were the first DNA elements found to regulate gene expression by delimiting chromatin contacts. We still do not know how many of them exist and what impact they have on the Drosophila genome folding. Contrary to vertebrates, there is no evidence that fly insulators block cohesi...

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Detalles Bibliográficos
Autores principales: Kahn, Tatyana G., Savitsky, Mikhail, Kuong, Chikuan, Jacquier, Caroline, Cavalli, Giacomo, Chang, Jia-Ming, Schwartz, Yuri B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9897668/
https://www.ncbi.nlm.nih.gov/pubmed/36735780
http://dx.doi.org/10.1126/sciadv.ade0090