Epistasis between promoter activity and coding mutations shapes gene evolvability

The evolution of protein-coding genes proceeds as mutations act on two main dimensions: regulation of transcription level and the coding sequence. The extent and impact of the connection between these two dimensions are largely unknown because they have generally been studied independently. By measu...

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Detalles Bibliográficos
Autores principales: Cisneros, Angel F., Gagnon-Arsenault, Isabelle, Dubé, Alexandre K., Després, Philippe C., Kumar, Pradum, Lafontaine, Kiana, Pelletier, Joelle N., Landry, Christian R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9897669/
https://www.ncbi.nlm.nih.gov/pubmed/36735790
http://dx.doi.org/10.1126/sciadv.add9109

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9897669/
https://www.ncbi.nlm.nih.gov/pubmed/36735790
http://dx.doi.org/10.1126/sciadv.add9109

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