Spatial regulation of the glycocalyx component podocalyxin is a switch for prometastatic function

The glycocalyx component and sialomucin podocalyxin (PODXL) is required for normal tissue development by promoting apical membranes to form between cells, triggering lumen formation. Elevated PODXL expression is also associated with metastasis and poor clinical outcome in multiple tumor types. How P...

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Detalles Bibliográficos
Autores principales: Román-Fernández, Alvaro, Mansour, Mohammed A., Kugeratski, Fernanda G., Anand, Jayanthi, Sandilands, Emma, Galbraith, Laura, Rakovic, Kai, Freckmann, Eva C., Cumming, Erin M., Park, Ji, Nikolatou, Konstantina, Lilla, Sergio, Shaw, Robin, Strachan, David, Mason, Susan, Patel, Rachana, McGarry, Lynn, Katoch, Archana, Campbell, Kirsteen J., Nixon, Colin, Miller, Crispin J., Leung, Hing Y., Le Quesne, John, Norman, James C., Zanivan, Sara, Blyth, Karen, Bryant, David M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9897673/
https://www.ncbi.nlm.nih.gov/pubmed/36735782
http://dx.doi.org/10.1126/sciadv.abq1858

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9897673/
https://www.ncbi.nlm.nih.gov/pubmed/36735782
http://dx.doi.org/10.1126/sciadv.abq1858

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