Discovery of new 6-ureido/amidocoumarins as highly potent and selective inhibitors for the tumour-relevant carbonic anhydrases IX and XII

A series of 6-ureido/amidocoumarins (5a–p and 7a–c) has been designed and synthesised to develop potent and isoform- selective carbonic anhydrase hCA XI and XII inhibitors. All coumarin derivatives were investigated for their CA inhibitory effect against hCA I, II, IX, and XII. Interestingly, target...

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Detalles Bibliográficos
Autores principales: El-Damasy, Ashraf K., Kim, Hyun Ji, Nocentini, Alessio, Seo, Seon Hee, Eldehna, Wagdy M., Bang, Eun-Kyoung, Supuran, Claudiu T., Keum, Gyochang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9897768/
https://www.ncbi.nlm.nih.gov/pubmed/36728712
http://dx.doi.org/10.1080/14756366.2022.2154603

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9897768/
https://www.ncbi.nlm.nih.gov/pubmed/36728712
http://dx.doi.org/10.1080/14756366.2022.2154603

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