Design, synthesis and cytotoxic evaluation of novel bis-thiazole derivatives as preferential Pim1 kinase inhibitors with in vivo and in silico study

Bis-thiazole derivatives were synthesised conforming to the Pim1 pharmacophore model following Hantzsch condensation. Pim1 has a major role in regulating the G1/S phase which upon inhibition the cell cycle stops at its early stages. Derivatives 3b and 8b showed the best Pim1 IC(50) 0.32 and 0.24 µM,...

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Detalles Bibliográficos
Autores principales: Al-Sanea, Mohammad M., Nasr, Tamer M., Bondock, Samir, Gawish, Aya Y., Mohamed, Nada M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9897788/
https://www.ncbi.nlm.nih.gov/pubmed/36728746
http://dx.doi.org/10.1080/14756366.2023.2166936

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9897788/
https://www.ncbi.nlm.nih.gov/pubmed/36728746
http://dx.doi.org/10.1080/14756366.2023.2166936

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