Cargando…

Discovery of novel 2-(4-(benzyloxy)-5-(hydroxyl) phenyl) benzothiazole derivatives as multifunctional MAO-B inhibitors for the treatment of Parkinson’s disease

To discover novel multifunctional agents for the treatment of Parkinson’s disease, a series of 2-(4-(benzyloxy)-5-(hydroxyl) phenyl) benzothiazole derivatives was designed, synthesized and evaluated. The results revealed that representative compound 3h possessed potent and selective MAO-B inhibitory...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cao, Zhongcheng, Wang, Xingyue, Zhang, Tianlong, Fu, Xianwu, Zhang, Fan, Zhu, Jiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2023
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9897792/ https://www.ncbi.nlm.nih.gov/pubmed/36728713 http://dx.doi.org/10.1080/14756366.2022.2159957

Ejemplares similares

Design and Synthesis of New Benzothiazole Compounds as Selective hMAO-B Inhibitors
por: Ilgın, Sinem, et al.
Publicado: (2017)

MAO-inhibitors in Parkinson's Disease
por: Riederer, Peter, et al.
Publicado: (2011)

[3,5-Bis(benzyloxy)phenyl]methanol
por: Zhu, Pei-Hua, et al.
Publicado: (2009)

5,7-Bis(benzyloxy)-2-[4-(benzyloxy)phenyl]-4H-chromen-4-one
por: Ren, Xu-Hong, et al.
Publicado: (2009)

Chasing ChEs-MAO B Multi-Targeting 4-Aminomethyl-7-Benzyloxy-2H-Chromen-2-ones
por: Rullo, Mariagrazia, et al.
Publicado: (2019)

Inhibitors of MAO-A and MAO-B in Psychiatry and Neurology
por: Finberg, John P. M., et al.
Publicado: (2016)

4-Decylphenyl 4-benzyloxy-3-methylbenzoate
por: Kashi, H. K. Arun, et al.
Publicado: (2010)

Rasagiline – a novel MAO B inhibitor in Parkinson’s disease therapy
por: Lecht, Shimon, et al.
Publicado: (2007)

A critical appraisal of MAO-B inhibitors in the treatment of Parkinson’s disease
por: Jost, Wolfgang H.
Publicado: (2022)

6-Benzyloxy-2-phenylpyridazin-3(2H)-one
por: Ju, Zhi-Yu, et al.
Publicado: (2012)

Effects of combined MAO-B inhibitors and levodopa vs. monotherapy in Parkinson’s disease
por: Krishna, Rakhee, et al.
Publicado: (2014)

Discovery of MAO-B Inhibitor with Machine Learning, Topomer CoMFA, Molecular Docking and Multi-Spectroscopy Approaches
por: Zheng, Linfeng, et al.
Publicado: (2022)

Reversible Small Molecule Inhibitors of MAO A and MAO B with Anilide Motifs
por: Hagenow, Jens, et al.
Publicado: (2020)

5-Chloro-2-phenyl-1,3-benzothiazole
por: Yousuf, Sammer, et al.
Publicado: (2012)

Monoamine oxidase-B (MAO-B) inhibitors: implications for disease-modification in Parkinson’s disease
por: Teo, Kay Cheong, et al.
Publicado: (2013)

5,7-Bis(benzyloxy)-2-phenyl-4H-chromen-4-one
por: Nallasivam, Angannan, et al.
Publicado: (2008)

4-(Benzyloxy)phenyl 4-hexadecyloxy-3-methoxybenzoate
por: Al-Eryani, Waleed Fadl Ali, et al.
Publicado: (2011)

1-Phenyl-N-(benzothiazol-2-yl)methanimine derivatives as Middle East respiratory syndrome coronavirus inhibitors
por: Hu, Min-Qi, et al.
Publicado: (2020)

Design, Synthesis and Evaluation of New Multifunctional Benzothiazoles as Photoprotective, Antioxidant and Antiproliferative Agents
por: Barbari, Riccardo, et al.
Publicado: (2022)

Research Progress of Benzothiazole and Benzoxazole Derivatives in the Discovery of Agricultural Chemicals
por: Zou, Yue, et al.
Publicado: (2023)

Maó
por: Quintana, Josep M. (Josep Maria)
Publicado: (1996)

1-(Benzyloxy)naphthalene
por: Venkatesan, Perumal, et al.
Publicado: (2011)

4-(Benzyloxy)benzaldehyde
por: Kennedy, Alan R., et al.
Publicado: (2010)

Synthesis and Evaluation of Hypoglycemic Activity of Structural Isomers of ((Benzyloxy)phenyl)propanoic Acid Bearing an Aminobornyl Moiety
por: Kuranov, Sergey O., et al.
Publicado: (2023)

New insights in the discovery of novel h-MAO-B inhibitors: structural characterization of a series of N-phenyl-4-oxo-4H-chromene-3-carboxamide derivatives
por: Gomes, Ligia R., et al.
Publicado: (2015)

Pharmacology of Rasagiline, a New MAO-B Inhibitor Drug for the Treatment of Parkinson’s Disease with Neuroprotective Potential
por: Finberg, John P.M.
Publicado: (2010)

Rotigotine in Combination with the MAO-B Inhibitor Selegiline in Early Parkinson’s Disease: A Post Hoc Analysis
por: Giladi, Nir, et al.
Publicado: (2016)

Isatin, an endogenous MAO inhibitor, and a rat model of Parkinson’s disease induced by the Japanese encephalitis virus
por: Minami, M., et al.
Publicado: (2006)

Novel Series of Dual NRF2 Inducers and Selective MAO-B Inhibitors for the Treatment of Parkinson’s Disease
por: Duarte, Pablo, et al.
Publicado: (2022)

Biological and Pharmacological Characterization of Benzothiazole-Based CK-1δ Inhibitors in Models of Parkinson’s Disease
por: Morales-Garcia, José A., et al.
Publicado: (2017)

8-Benzyloxy-2-methyl-3-(2-methylphenyl)quinazolin-4(3H)-one
por: El-Azab, Adel S., et al.
Publicado: (2012)

(E)-2-(4-Benzyloxy-2-hydroxybenzylidene)-N-phenylhydrazinecarbothioamide
por: Nisha, K., et al.
Publicado: (2011)

Diacetato{4′-[4-(benzyloxy)phenyl]-2,2′:6′,2′′-terpyridine}zinc(II)
por: Li, Wei, et al.
Publicado: (2009)

Mao : a biography /
por: Terrill, Ross
Publicado: (1981)

Mao Zedong
por: Grimm, Tilemann
Publicado: (1986)

2-Benzyloxy-1-naphthaldehyde
por: Gao, Rong, et al.
Publicado: (2009)

The Antiproliferative Effects of Flavonoid MAO Inhibitors on Prostate Cancer Cells
por: Zarmouh, Najla O., et al.
Publicado: (2020)

MAO-B Elevation in Mouse Brain Astrocytes Results in Parkinson's Pathology
por: Mallajosyula, Jyothi K., et al.
Publicado: (2008)

KDS2010, a Newly Developed Reversible MAO-B Inhibitor, as an Effective Therapeutic Candidate for Parkinson’s Disease
por: Nam, Min-Ho, et al.
Publicado: (2021)

Effects of MAO-B inhibitors on non-motor symptoms and quality of life in Parkinson’s disease: A systematic review
por: Tsuboi, Takashi, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_f8eirm6tsc0s5cl6cg96759f8h