Emergence of a proton exchange-based isomerization and lactonization mechanism in the plant coumarin synthase COSY

Plants contain rapidly evolving specialized enzymes that support the biosynthesis of functionally diverse natural products. In coumarin biosynthesis, a BAHD acyltransferase-family enzyme COSY was recently discovered to accelerate coumarin formation as the only known BAHD enzyme to catalyze an intram...

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Detalles Bibliográficos
Autores principales: Kim, Colin Y., Mitchell, Andrew J., Kastner, David W., Albright, Claire E., Gutierrez, Michael A., Glinkerman, Christopher M., Kulik, Heather J., Weng, Jing-Ke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9898226/
https://www.ncbi.nlm.nih.gov/pubmed/36737607
http://dx.doi.org/10.1038/s41467-023-36299-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9898226/
https://www.ncbi.nlm.nih.gov/pubmed/36737607
http://dx.doi.org/10.1038/s41467-023-36299-1

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