Cargando…

Leflunomide abrogates neuroinflammatory changes in a rat model of Alzheimer’s disease: the role of TNF-α/NF-κB/IL-1β axis inhibition

Alzheimer’s disease (AD) is one of the most common neurodegenerative diseases and is associated with disrupted cognition and behavior. Neuroinflammatory pathogenesis is the main component that contributes to AD initiation and progression through microglial activation and neuronal damage. Thus, targe...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nafea, Menna, Elharoun, Mona, Abd-Alhaseeb, Mohammad Mohmoud, Helmy, Maged Wasfy
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9898334/ https://www.ncbi.nlm.nih.gov/pubmed/36385687 http://dx.doi.org/10.1007/s00210-022-02322-3

Ejemplares similares

Systemic bee venom exerts anti-arthritic and anti-inflammatory properties in a rat model of arthritis
por: El-Tedawy, Doaa Mohamed, et al.
Publicado: (2020)

Divergent Neuroinflammatory Regulation of Microglial TREM Expression and Involvement of NF-κB
por: Owens, Rosie, et al.
Publicado: (2017)

Neuroprotective Effect of Barbaloin on Streptozotocin-Induced Cognitive Dysfunction in Rats via Inhibiting Cholinergic and Neuroinflammatory Cytokines Pathway—TNF-α/IL-1β/IL-6/NF-κB
por: Omer, Asma B., et al.
Publicado: (2023)

Corrigendum: Divergent Neuroinflammatory Regulation of Microglial TREM Expression and Involvement of NF-κB
por: Owens, Rosie, et al.
Publicado: (2017)

Intrapulmonary administration of purified NEIL2 abrogates NF-κB–mediated inflammation
por: Tapryal, Nisha, et al.
Publicado: (2021)

Anti-Neuroinflammatory Effect of Alantolactone through the Suppression of the NF-κB and MAPK Signaling Pathways
por: Tan, Liwei, et al.
Publicado: (2019)

Phytochemicals against TNFα-Mediated Neuroinflammatory Diseases
por: Subedi, Lalita, et al.
Publicado: (2020)

Autotaxin expression and its connection with the TNF-alpha-NF-κB axis in human hepatocellular carcinoma
por: Wu, Jian-Min, et al.
Publicado: (2010)

Leflunomide Inhibits rat-to-Mouse Cardiac Xenograft Rejection by Suppressing Adaptive Immune Cell Response and NF-κB Signaling Activation
por: Ma, Yunhan, et al.
Publicado: (2021)

Galangin Abrogates Ovalbumin-Induced Airway Inflammation via Negative Regulation of NF-κB
por: Zha, Wang-Jian, et al.
Publicado: (2013)

Transgenic inhibition of astroglial NF-κB restrains the neuroinflammatory and neurodegenerative outcomes of experimental mouse glaucoma
por: Yang, Xiangjun, et al.
Publicado: (2020)

NF-κB-DICER-miRs Axis Regulates TNF-α Expression in Responses to Endotoxin Stress
por: Guan, Yi, et al.
Publicado: (2015)

Microenvironmental stromal cells abrogate NF-κB inhibitor-induced apoptosis in chronic lymphocytic leukemia
por: Simon-Gabriel, Carl Philipp, et al.
Publicado: (2018)

Brazilian Green Propolis Suppresses the Hypoxia-Induced Neuroinflammatory Responses by Inhibiting NF-κB Activation in Microglia
por: Wu, Zhou, et al.
Publicado: (2013)

ATM-NFκB axis-driven TIGAR regulates sensitivity of glioma cells to radiomimetics in the presence of TNFα
por: Sinha, S, et al.
Publicado: (2013)

MCPIP1 Enhances TNF-α-Mediated Apoptosis through Downregulation of the NF-κB/cFLIP Axis
por: Suk, Fat-Moon, et al.
Publicado: (2021)

Leflunomide-Induced Hidradenitis Suppurativa
por: Machan, Achraf, et al.
Publicado: (2020)

Arsenic trioxide, a potent inhibitor of NF-κB, abrogates allergen-induced airway hyperresponsiveness and inflammation
por: Zhou, Lin-Fu, et al.
Publicado: (2006)

Bajijiasu Abrogates Osteoclast Differentiation via the Suppression of RANKL Signaling Pathways through NF-κB and NFAT
por: Hong, Guoju, et al.
Publicado: (2017)

Alizarin, a nature compound, inhibits the growth of pancreatic cancer cells by abrogating NF-κB activation
por: Xu, Zihang, et al.
Publicado: (2022)

Single TNFα trimers mediating NF-κB activation: stochastic robustness of NF-κB signaling
por: Lipniacki, Tomasz, et al.
Publicado: (2007)

Epigenetic restoration and activation of ERβ: an inspiring approach for treatment of triple-negative breast cancer
por: Salahuddin, Ahmad, et al.
Publicado: (2022)

Neuroinflammatory Response to TNFα and IL1β Cytokines Is Accompanied by an Increase in Glycolysis in Human Astrocytes In Vitro
por: Pamies, David, et al.
Publicado: (2021)

Leflunomide leads to inhibition of transendothelial migration
por: Grisar, J, et al.
Publicado: (2001)

Breast cancer metastasis suppressor 1 (BRMS1) inhibits osteopontin transcription by abrogating NF-κB activation
por: Samant, Rajeev S, et al.
Publicado: (2007)

Haloperidol Abrogates Matrix Metalloproteinase-9 Expression by Inhibition of NF-κB Activation in Stimulated Human Monocytic Cells
por: Lee, Yueh-Lun, et al.
Publicado: (2018)

Aspirin enhances the sensitivity of colon cancer cells to cisplatin by abrogating the binding of NF-κB to the COX-2 promoter
por: Jiang, Wei, et al.
Publicado: (2020)

BHDPC Is a Novel Neuroprotectant That Provides Anti-neuroinflammatory and Neuroprotective Effects by Inactivating NF-κB and Activating PKA/CREB
por: Li, Chuwen, et al.
Publicado: (2018)

Tabersonine Inhibits the Lipopolysaccharide-Induced Neuroinflammatory Response in BV2 Microglia Cells via the NF-κB Signaling Pathway
por: Shi, Jiaotai, et al.
Publicado: (2022)

Effect of coadministration of omega-3 fatty acids with glimepiride on glycemic control, lipid profile, irisin, and sirtuin-1 in type 2 diabetes mellitus patients: a randomized controlled trial
por: Werida, Rehab H., et al.
Publicado: (2023)

Design, Optimization and Characterization of a Transfersomal Gel Using Miconazole Nitrate for the Treatment of Candida Skin Infections
por: Qushawy, Mona, et al.
Publicado: (2018)

Inflammation, cytokines, the IL-17/IL-6/STAT3/NF-κB axis, and tumorigenesis
por: Chen, Xiao-Wu, et al.
Publicado: (2015)

Peptide-Protected Gold Nanoclusters Efficiently Ameliorate Acute Contact Dermatitis and Psoriasis via Repressing the TNF-α/NF-κB/IL-17A Axis in Keratinocytes
por: Liu, Yu, et al.
Publicado: (2023)

Murine Gamma Herpesvirus 68 Hijacks MAVS and IKKβ to Abrogate NFκB Activation and Antiviral Cytokine Production
por: Dong, Xiaonan, et al.
Publicado: (2011)

Pharmacological targeting of β-adrenergic receptor functions abrogates NF-κB signaling and MMP-9 secretion in medulloblastoma cells
por: Annabi, Borhane, et al.
Publicado: (2010)

MicroRNA-21 abrogates palmitate-induced cardiomyocyte apoptosis through caspase-3/NF-κB signal pathways
por: Zhou, Xiaodi, et al.
Publicado: (2018)

Abrogating ClC-3 Inhibits LPS-induced Inflammation via Blocking the TLR4/NF-κB Pathway
por: Xiang, Nan-lin, et al.
Publicado: (2016)

TNF activation of NF-κB is essential for development of single-positive thymocytes
por: Webb, Louise V., et al.
Publicado: (2016)

Effect of Leflunomide–Metal Complexes on ROS, TNF, and Brain Indolamines in Comparison with Anti-Depressants as Adjunct Therapy in Rheumatoid Arthritic Model
por: Naeem, Almas, et al.
Publicado: (2023)

Sustained, neuron-specific IKK/NF-κB activation generates a selective neuroinflammatory response promoting local neurodegeneration with aging
por: Maqbool, Ayesha, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_lrdce5n7nj4p3v1mmirgmlvt6p