Evaluation of Neonatal and Paediatric Vancomycin Pharmacokinetic Models and the Impact of Maturation and Serum Creatinine Covariates in a Large Multicentre Data Set

BACKGROUND AND OBJECTIVE: Infants and neonates present a clinical challenge for dosing drugs with high interindividual variability due to these patients’ rapid growth and the interplay between maturation and organ function. Model-informed precision dosing (MIPD), which can account for interindividua...

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Detalles Bibliográficos
Autores principales: Hughes, Jasmine H., Tong, Dominic M. H., Faldasz, Jonathan D., Frymoyer, Adam, Keizer, Ron J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9898357/
https://www.ncbi.nlm.nih.gov/pubmed/36404388
http://dx.doi.org/10.1007/s40262-022-01185-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9898357/
https://www.ncbi.nlm.nih.gov/pubmed/36404388
http://dx.doi.org/10.1007/s40262-022-01185-4

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