A physiologically based pharmacokinetic model for [(68)Ga]Ga-(HA-)DOTATATE to predict whole-body distribution and tumor sink effects in GEP-NET patients

BACKGROUND: Little is known about parameters that have a relevant impact on (dis)similarities in biodistribution between various (68)Ga-labeled somatostatin analogues. Additionally, the effect of tumor burden on organ uptake remains unclear. Therefore, the aim of this study was to describe and compa...

Descripción completa

Detalles Bibliográficos
Autores principales: Siebinga, Hinke, de Wit-van der Veen, Berlinda J., Beijnen, Jos H., Dorlo, Thomas P. C., Huitema, Alwin D. R., Hendrikx, Jeroen J. M. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9898489/
https://www.ncbi.nlm.nih.gov/pubmed/36735114
http://dx.doi.org/10.1186/s13550-023-00958-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9898489/
https://www.ncbi.nlm.nih.gov/pubmed/36735114
http://dx.doi.org/10.1186/s13550-023-00958-7

Ejemplares similares