Alternative polyadenylation transcriptome-wide association study identifies APA-linked susceptibility genes in brain disorders

Alternative polyadenylation (APA) plays an essential role in brain development; however, current transcriptome-wide association studies (TWAS) largely overlook APA in nominating susceptibility genes. Here, we performed a 3′ untranslated region (3′UTR) APA TWAS (3′aTWAS) for 11 brain disorders by com...

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Detalles Bibliográficos
Autores principales: Cui, Ya, Arnold, Frederick J., Peng, Fanglue, Wang, Dan, Li, Jason Sheng, Michels, Sebastian, Wagner, Eric J., La Spada, Albert R., Li, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9898543/
https://www.ncbi.nlm.nih.gov/pubmed/36737438
http://dx.doi.org/10.1038/s41467-023-36311-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9898543/
https://www.ncbi.nlm.nih.gov/pubmed/36737438
http://dx.doi.org/10.1038/s41467-023-36311-8

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