Inhibition of miR338 rescues cleidocranial dysplasia in Runx2 mutant mice partially via the Hif1a-Vegfa axis

Haploinsufficiency of Runt-related transcription factor-2 (RUNX2) is responsible for cleidocranial dysplasia (CCD), a rare hereditary disease with a range of defects, including delayed closure of the cranial sutures and short stature. Symptom-based treatments, such as a combined surgical-orthodontic...

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Detalles Bibliográficos
Autores principales: Jin, Runze, Zhang, Hanshu, Lin, Chujiao, Guo, Jinqiang, Zou, Weiguo, Chen, Zhi, Liu, Huan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9898552/
https://www.ncbi.nlm.nih.gov/pubmed/36599929
http://dx.doi.org/10.1038/s12276-022-00914-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9898552/
https://www.ncbi.nlm.nih.gov/pubmed/36599929
http://dx.doi.org/10.1038/s12276-022-00914-w

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