Npm1 haploinsufficiency in collaboration with MEIS1 is sufficient to induce AML in mice

NPM1 is among the most frequently mutated genes in acute myeloid leukemia (AML). Mutations in the NPM1 gene result in the increased export of NPM1 to the cytoplasm (NPM1c) and are associated with multiple transforming events including the aberrant upregulation of MEIS1 that maintains stem cell and c...

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Detalles Bibliográficos
Autores principales: Muranyi, Andrew, Ammer, Tobias, Kechter, Anna, Rawat, Vijay P.S., Sinha, Amit, Gonzalez-Menendez, Irene, Quintanilla-Martinez, Leticia, Azoitei, Anca, Günes, Cagatay, Mupo, Annalisa, Vassiliou, George, Bamezai, Shiva, Buske, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Hematology 2022
Materias:
Myeloid Neoplasia
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9898611/
https://www.ncbi.nlm.nih.gov/pubmed/35468619
http://dx.doi.org/10.1182/bloodadvances.2022007015

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9898611/
https://www.ncbi.nlm.nih.gov/pubmed/35468619
http://dx.doi.org/10.1182/bloodadvances.2022007015

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