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Analysis of a degron-containing reporter protein GFP-CL1 reveals a role for SUMO1 in cytosolic protein quality control
Misfolded proteins are recognized and degraded through protein quality control (PQC) pathways, which are essential for maintaining proteostasis and normal cellular functions. Defects in PQC can result in disease, including cancer, cardiovascular disease, and neurodegeneration. The small ubiquitin-re...
Autores principales: | Wang, Wei, Lu, Jian, Yang, Wei-Chih, Spear, Eric D., Michaelis, Susan, Matunis, Michael J. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Biochemistry and Molecular Biology
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9898758/ https://www.ncbi.nlm.nih.gov/pubmed/36587767 http://dx.doi.org/10.1016/j.jbc.2022.102851 |
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