A liquid-to-solid phase transition of Cu/Zn superoxide dismutase 1 initiated by oxidation and disease mutation

Cu/Zn superoxide dismutase 1 (SOD1) has a high propensity to misfold and form abnormal aggregates when it is subjected to oxidative stress or carries mutations associated with amyotrophic lateral sclerosis. However, the transition from functional soluble SOD1 protein to aggregated SOD1 protein is no...

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Detalles Bibliográficos
Autores principales: Gu, Siyu, Xu, Ming, Chen, Long, Shi, Xiangyan, Luo, Shi-Zhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9898760/
https://www.ncbi.nlm.nih.gov/pubmed/36592929
http://dx.doi.org/10.1016/j.jbc.2022.102857

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9898760/
https://www.ncbi.nlm.nih.gov/pubmed/36592929
http://dx.doi.org/10.1016/j.jbc.2022.102857

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