A Push–Pull Mechanism Between PRRT2 and β4-subunit Differentially Regulates Membrane Exposure and Biophysical Properties of NaV1.2 Sodium Channels

Proline-rich transmembrane protein 2 (PRRT2) is a neuron-specific protein implicated in the control of neurotransmitter release and neural network stability. Accordingly, PRRT2 loss-of-function mutations associate with pleiotropic paroxysmal neurological disorders, including paroxysmal kinesigenic d...

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Detalles Bibliográficos
Autores principales: Valente, Pierluigi, Marte, Antonella, Franchi, Francesca, Sterlini, Bruno, Casagrande, Silvia, Corradi, Anna, Baldelli, Pietro, Benfenati, Fabio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9899197/
https://www.ncbi.nlm.nih.gov/pubmed/36441479
http://dx.doi.org/10.1007/s12035-022-03112-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9899197/
https://www.ncbi.nlm.nih.gov/pubmed/36441479
http://dx.doi.org/10.1007/s12035-022-03112-x

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