Parkinsonism mutations in DNAJC6 cause lipid defects and neurodegeneration that are rescued by Synj1

Recent evidence links dysfunctional lipid metabolism to the pathogenesis of Parkinson’s disease, but the mechanisms are not resolved. Here, we generated a new Drosophila knock-in model of DNAJC6/Auxilin and find that the pathogenic mutation causes synaptic dysfunction, neurological defects and neuro...

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Detalles Bibliográficos
Autores principales: Jacquemyn, Julie, Kuenen, Sabine, Swerts, Jef, Pavie, Benjamin, Vijayan, Vinoy, Kilic, Ayse, Chabot, Dries, Wang, Yu-Chun, Schoovaerts, Nils, Corthout, Nikky, Verstreken, Patrik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9899244/
https://www.ncbi.nlm.nih.gov/pubmed/36739293
http://dx.doi.org/10.1038/s41531-023-00459-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9899244/
https://www.ncbi.nlm.nih.gov/pubmed/36739293
http://dx.doi.org/10.1038/s41531-023-00459-3

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