Cargando…

The GSK3β/Mcl-1 axis is regulated by both FLT3-ITD and Axl and determines the apoptosis induction abilities of FLT3-ITD inhibitors

Acute myeloid leukemia (AML) patients with FLT3-ITD mutations are associated with poor prognosis. FLT3-ITD inhibitors are developed and result in transient disease remission, but generally resistance develops. We propose that resistance occurs due to apoptosis evasion. We compared the abilities of f...

Descripción completa

Detalles Bibliográficos
Autores principales: Qiu, Yang, Li, Ying, Chai, Meng, Hua, Huiming, Wang, Rui, Waxman, Samuel, Jing, Yongkui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9899255/
https://www.ncbi.nlm.nih.gov/pubmed/36739272
http://dx.doi.org/10.1038/s41420-023-01317-0