The GSK3β/Mcl-1 axis is regulated by both FLT3-ITD and Axl and determines the apoptosis induction abilities of FLT3-ITD inhibitors

Acute myeloid leukemia (AML) patients with FLT3-ITD mutations are associated with poor prognosis. FLT3-ITD inhibitors are developed and result in transient disease remission, but generally resistance develops. We propose that resistance occurs due to apoptosis evasion. We compared the abilities of f...

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Detalles Bibliográficos
Autores principales: Qiu, Yang, Li, Ying, Chai, Meng, Hua, Huiming, Wang, Rui, Waxman, Samuel, Jing, Yongkui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9899255/
https://www.ncbi.nlm.nih.gov/pubmed/36739272
http://dx.doi.org/10.1038/s41420-023-01317-0

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