ESCRT-dependent STING degradation inhibits steady-state and cGAMP-induced signalling

Stimulator of interferon genes (STING) is an intracellular sensor of cyclic di-nucleotides involved in the innate immune response against pathogen- or self-derived DNA. STING trafficking is tightly linked to its function, and its dysregulation can lead to disease. Here, we systematically characteriz...

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Detalles Bibliográficos
Autores principales: Gentili, Matteo, Liu, Bingxu, Papanastasiou, Malvina, Dele-Oni, Deborah, Schwartz, Marc A., Carlson, Rebecca J., Al’Khafaji, Aziz M., Krug, Karsten, Brown, Adam, Doench, John G., Carr, Steven A., Hacohen, Nir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9899276/
https://www.ncbi.nlm.nih.gov/pubmed/36739287
http://dx.doi.org/10.1038/s41467-023-36132-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9899276/
https://www.ncbi.nlm.nih.gov/pubmed/36739287
http://dx.doi.org/10.1038/s41467-023-36132-9

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