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Proteolytic cleavage of membrane proteins by membrane type‐1 MMP regulates cancer malignant progression

Strategies to develop cancer therapies using inhibitors that target matrix metalloproteinases (MMPs), particularly membrane type‐1 MMP (MT1‐MMP), have failed. This is predominantly attributed to the specificity of MMP inhibitors and numerous functions of MMPs; therefore, targeting substrates with su...

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Detalles Bibliográficos
Autores principales: Ikeda, Kazuki, Kaneko, Ryo, Tsukamoto, Eiki, Funahashi, Nobuaki, Koshikawa, Naohiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9899627/
https://www.ncbi.nlm.nih.gov/pubmed/36336966
http://dx.doi.org/10.1111/cas.15638