Dual-AAV split prime editor corrects the mutation and phenotype in mice with inherited retinal degeneration

The prime editor (PE) can edit genomes with almost any intended changes, including all 12 possible types of base substitutions, small insertions and deletions, and their combinations, without the requirement for double strand breaks or exogenous donor templates. PE demonstrates the possibility of co...

Descripción completa

Detalles Bibliográficos
Autores principales: She, Kaiqin, Liu, Yi, Zhao, Qinyu, Jin, Xiu, Yang, Yiliu, Su, Jing, Li, Ruiting, Song, Li, Xiao, Jianlu, Yao, Shaohua, Lu, Fang, Wei, Yuquan, Yang, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9899767/
https://www.ncbi.nlm.nih.gov/pubmed/36740702
http://dx.doi.org/10.1038/s41392-022-01234-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9899767/
https://www.ncbi.nlm.nih.gov/pubmed/36740702
http://dx.doi.org/10.1038/s41392-022-01234-1

Ejemplares similares