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Dual-AAV split prime editor corrects the mutation and phenotype in mice with inherited retinal degeneration
The prime editor (PE) can edit genomes with almost any intended changes, including all 12 possible types of base substitutions, small insertions and deletions, and their combinations, without the requirement for double strand breaks or exogenous donor templates. PE demonstrates the possibility of co...
| Autores principales: | , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9899767/ https://www.ncbi.nlm.nih.gov/pubmed/36740702 http://dx.doi.org/10.1038/s41392-022-01234-1 |