A Dynamic rRNA Ribomethylome Drives Stemness in Acute Myeloid Leukemia

The development and regulation of malignant self-renewal remain unresolved issues. Here, we provide biochemical, genetic, and functional evidence that dynamics in ribosomal RNA (rRNA) 2′-O-methylation regulate leukemia stem cell (LSC) activity in vivo. A comprehensive analysis of the rRNA 2′-O-methy...

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Detalles Bibliográficos
Autores principales: Zhou, Fengbiao, Aroua, Nesrine, Liu, Yi, Rohde, Christian, Cheng, Jingdong, Wirth, Anna-Katharina, Fijalkowska, Daria, Göllner, Stefanie, Lotze, Michelle, Yun, Haiyang, Yu, Xiaobing, Pabst, Caroline, Sauer, Tim, Oellerich, Thomas, Serve, Hubert, Röllig, Christoph, Bornhäuser, Martin, Thiede, Christian, Baldus, Claudia, Frye, Michaela, Raffel, Simon, Krijgsveld, Jeroen, Jeremias, Irmela, Beckmann, Roland, Trumpp, Andreas, Müller-Tidow, Carsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Research Briefs
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9900322/
https://www.ncbi.nlm.nih.gov/pubmed/36259929
http://dx.doi.org/10.1158/2159-8290.CD-22-0210

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9900322/
https://www.ncbi.nlm.nih.gov/pubmed/36259929
http://dx.doi.org/10.1158/2159-8290.CD-22-0210

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