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Engineering poly- and micelleplexes for nucleic acid delivery – A reflection on their endosomal escape

For the longest time, the field of nucleic acid delivery has remained skeptical whether or not polycationic drug carrier systems would ever make it into clinical practice. Yet, with the disclosure of patents on polyethyleneimine-based RNA carriers through leading companies in the field of nucleic ac...

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Detalles Bibliográficos
Autores principales: Winkeljann, Benjamin, Keul, David C., Merkel, Olivia M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science Publishers 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9900387/
https://www.ncbi.nlm.nih.gov/pubmed/36496051
http://dx.doi.org/10.1016/j.jconrel.2022.12.008