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Rate of tau propagation is a heritable disease trait in genetically diverse mouse strains

The speed and scope of cognitive deterioration in Alzheimer's disease is highly associated with the advancement of tau neurofibrillary lesions across brain networks. We tested whether the rate of tau propagation is a heritable disease trait in a large, well-characterized cohort of genetically d...

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Detalles Bibliográficos
Autores principales: Welikovitch, Lindsay A., Dujardin, Simon, Dunn, Amy R., Fernandes, Analiese R., Khasnavis, Anita, Chibnik, Lori B., Kaczorowski, Catherine C., Hyman, Bradley T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9900390/
https://www.ncbi.nlm.nih.gov/pubmed/36756365
http://dx.doi.org/10.1016/j.isci.2023.105983