Compressed Perturb-seq: highly efficient screens for regulatory circuits using random composite perturbations

Pooled CRISPR screens with single-cell RNA-seq readout (Perturb-seq) have emerged as a key technique in functional genomics, but are limited in scale by cost and combinatorial complexity. Here, we reimagine Perturb-seq’s design through the lens of algorithms applied to random, low-dimensional observ...

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Detalles Bibliográficos
Autores principales: Yao, Douglas, Binan, Loic, Bezney, Jon, Simonton, Brooke, Freedman, Jahanara, Frangieh, Chris J., Dey, Kushal, Geiger-Schuller, Kathryn, Eraslan, Basak, Gusev, Alexander, Regev, Aviv, Cleary, Brian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9900787/
https://www.ncbi.nlm.nih.gov/pubmed/36747806
http://dx.doi.org/10.1101/2023.01.23.525200

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9900787/
https://www.ncbi.nlm.nih.gov/pubmed/36747806
http://dx.doi.org/10.1101/2023.01.23.525200

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