Nuclease-dead S. aureus Cas9 downregulates alpha-synuclein and reduces mtDNA damage and oxidative stress levels in patient-derived stem cell model of Parkinson’s disease

Parkinson’s disease (PD) is one of the most common neurodegenerative diseases, but no disease modifying therapies have been successful in clinical translation presenting a major unmet medical need. A promising target is alpha-synuclein or its aggregated form, which accumulates in the brain of PD pat...

Descripción completa

Detalles Bibliográficos
Autores principales: Sastre, Danuta, Zafar, Faria, Torres, C. Alejandra Morato, Piper, Desiree, Kirik, Deniz, Sanders, Laurie H., Qi, Stanley, Schüle, Birgitt
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9900844/
https://www.ncbi.nlm.nih.gov/pubmed/36747875
http://dx.doi.org/10.1101/2023.01.24.525105

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9900844/
https://www.ncbi.nlm.nih.gov/pubmed/36747875
http://dx.doi.org/10.1101/2023.01.24.525105

Ejemplares similares