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IRF1 regulates self-renewal and stress-responsiveness to support hematopoietic stem cell maintenance

Inflammatory mediators induce emergency myelopoiesis and cycling of adult hematopoietic stem cells (HSCs) through incompletely understood mechanisms. To suppress the unwanted effects of inflammation and preserve its beneficial outcomes, the mechanisms by which inflammation affects hematopoiesis need...

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Detalles Bibliográficos
Autores principales: Rundberg Nilsson, Alexandra, Xian, Hongxu, Shalapour, Shabnam, Cammenga, Jörg, Karin, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9900858/
https://www.ncbi.nlm.nih.gov/pubmed/36747722
http://dx.doi.org/10.1101/2023.01.24.525321