Cargando…

Accumulation of TCR signaling from self-antigens in naive CD8 T cells mitigates early responsiveness

The cumulative effects of T cell receptor (TCR) signal transduction over extended periods of time influences T cell biology, such as the positive selection of immature thymocytes or the proliferative responses of naive T cells. Naive T cells experience recurrent TCR signaling in response to self-ant...

Descripción completa

Detalles Bibliográficos
Autores principales:	Eggert, Joel, Zinzow-Kramer, Wendy M., Hu, Yuesong, Tsai, Yuan-Li, Weiss, Arthur, Salaita, Khalid, Scharer, Christopher D., Au-Yeung, Byron B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9900884/ https://www.ncbi.nlm.nih.gov/pubmed/36747815 http://dx.doi.org/10.1101/2023.01.27.525946

Ejemplares similares

The magnitude of LFA-1/ICAM-1 forces fine-tune TCR-triggered T cell activation
por: Ma, Victor Pui-Yan, et al.
Publicado: (2022)

The phosphatidylinositol-transfer protein Nir3 promotes PI(4,5)P(2) replenishment in response to TCR signaling during T cell development and survival
por: Lu, Wen, et al.
Publicado: (2022)

Pak2 is required for actin cytoskeleton remodeling, TCR signaling, and normal thymocyte development and maturation
por: Phee, Hyewon, et al.
Publicado: (2014)

Force-induced site-specific enzymatic cleavage probes reveal that serial mechanical engagement boosts T cell activation
por: Rogers, Jhordan, et al.
Publicado: (2023)

Naive and memory T cells TCR–HLA-binding prediction
por: Glazer, Neta, et al.
Publicado: (2022)

Common distal elements orchestrate CIITA isoform-specific expression in multiple cell types
por: Lohsen, Sarah, et al.
Publicado: (2014)

Endogenous antigen tunes the responsiveness of naive B cells but not T cells
por: Zikherman, Julie, et al.
Publicado: (2012)

Naive CD8(+) T-cell precursors display structured TCR repertoires and composite antigen-driven selection dynamics
por: Neller, Michelle A, et al.
Publicado: (2015)

The TCR’s sensitivity to self-peptide–MHC dictates the ability of naïve CD8(+) T cells to respond to foreign antigens
por: Fulton, Ross B., et al.
Publicado: (2014)

Naïve T Cell Homeostasis Regulated by Stress Responses and TCR Signaling
por: Kamimura, Daisuke, et al.
Publicado: (2015)

DNA Origami Tension Sensors (DOTS) to study T cell receptor mechanics at membrane junctions
por: Hu, Yuesong, et al.
Publicado: (2023)

Twisting tails exposed: the evidence for TCR conformational change
por: Levin, Susan E., et al.
Publicado: (2005)

Src-like adaptor protein down-regulates T cell receptor (TCR)–CD3 expression by targeting TCRζ for degradation
por: Myers, Margaret D., et al.
Publicado: (2005)

A TCR-based Chimeric Antigen Receptor
por: Walseng, Even, et al.
Publicado: (2017)

CD45-mediated control of TCR tuning in naïve and memory CD8(+) T cells
por: Cho, Jae-Ho, et al.
Publicado: (2016)

Stoichiometry of the T cell antigen receptor (TCR) complex: each TCR/CD3 complex contains one TCR alpha, one TCR beta, and two CD3 epsilon chains
Publicado: (1994)

Mitigation of age-dependent accumulation of defective mitochondrial genomes
por: Tsai, Pei-I, et al.
Publicado: (2022)

TCR and CD28 Concomitant Stimulation Elicits a Distinctive Calcium Response in Naive T Cells
por: Xia, Fan, et al.
Publicado: (2018)

TCR sequencing: applications in immuno-oncology research
por: Sanromán, Á.F., et al.
Publicado: (2023)

Control of T cell antigen reactivity via programmed TCR downregulation
por: Gallegos, Alena M, et al.
Publicado: (2016)

Biased MAIT TCR Usage Poised for Limited Antigen Diversity?
por: Souter, Michael N. T., et al.
Publicado: (2020)

Rapid regulatory evolution of a nonrecombining autosome linked to divergent behavioral phenotypes
por: Sun, Dan, et al.
Publicado: (2018)

Nuclear pore complex-mediated modulation of TCR signaling is required for naïve CD4(+) T cell homeostasis
por: Borlido, Joana, et al.
Publicado: (2018)

A novel antibody-TCR (AbTCR) platform combines Fab-based antigen recognition with gamma/delta-TCR signaling to facilitate T-cell cytotoxicity with low cytokine release
por: Xu, Yiyang, et al.
Publicado: (2018)

Imaging vesicle formation dynamics supports the flexible model of clathrin-mediated endocytosis
por: Nawara, Tomasz J., et al.
Publicado: (2022)

Structure of the T cell antigen receptor (TCR): two CD3 epsilon subunits in a functional TCR/CD3 complex
Publicado: (1991)

Modifications outside CDR1, 2 and 3 of the TCR variable β domain increase TCR expression and antigen-specific function
por: Degirmencay, Abdullah, et al.
Publicado: (2023)

Naïve Arrogance and Vulnerability
por: Breedlove, Byron, et al.
Publicado: (2017)

The TCR is randomly distributed on the plasma membrane of resting antigen-experienced T cells
por: Rossboth, Benedikt, et al.
Publicado: (2018)

Akt and STAT5 mediate naïve human CD4+ T-cell early metabolic response to TCR stimulation
por: Jones, Nicholas, et al.
Publicado: (2019)

Tumor-Resident Dendritic Cells and Macrophages Modulate the Accumulation of TCR-Engineered T Cells in Melanoma
por: Hotblack, Alastair, et al.
Publicado: (2018)

Pre-TCRα and TCRα Are Not Interchangeable Partners of TCRβ during T Lymphocyte Development
por: Borowski, Christine, et al.
Publicado: (2004)

Tyrosine Phosphorylation of Pyk2 Is Selectively Regulated by Fyn During TCR Signaling
por: Qian, Dapeng, et al.
Publicado: (1997)

Structure of TCR and antigen complexes at an immunodominant CTL epitope in HIV-1 infection
por: Shimizu, Akihisa, et al.
Publicado: (2013)

Predicting antigen specificity of single T cells based on TCR CDR3 regions
por: Fischer, David S, et al.
Publicado: (2020)

TCR-Like CAR-T Cells Targeting MHC-Bound Minor Histocompatibility Antigens
por: Akatsuka, Yoshiki
Publicado: (2020)

Tissue-specific shaping of the TCR repertoire and antigen specificity of iNKT cells
por: Jimeno, Rebeca, et al.
Publicado: (2019)

Antigen-Specific TCR-T Cells for Acute Myeloid Leukemia: State of the Art and Challenges
por: Kang, Synat, et al.
Publicado: (2022)

Administration of rhIL-7 in humans increases in vivo TCR repertoire diversity by preferential expansion of naive T cell subsets
por: Sportès, Claude, et al.
Publicado: (2008)

miR-20a Inhibits TCR-Mediated Signaling and Cytokine Production in Human Naïve CD4(+) T Cells
por: Reddycherla, Amarendra V., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_j9r916jgbr9qpea30421htgq9b