Structural characterization of HIV-1 Env heterotrimers bound to one or two CD4 receptors reveals intermediate Env conformations

HIV-1 envelope (Env) exhibits distinct conformational changes in response to host receptor (CD4) engagement. Env, a trimer of gp120/gp41 heterodimers, has been structurally characterized in a closed, prefusion conformation with closely associated gp120s and coreceptor binding sites on gp120 V3 hidde...

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Detalles Bibliográficos
Autores principales: Dam, Kim-Marie A., Fan, Chengcheng, Yang, Zhi, Bjorkman, Pamela J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9900888/
https://www.ncbi.nlm.nih.gov/pubmed/36747804
http://dx.doi.org/10.1101/2023.01.27.525985

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9900888/
https://www.ncbi.nlm.nih.gov/pubmed/36747804
http://dx.doi.org/10.1101/2023.01.27.525985

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