How PTEN mutations degrade function at the membrane and life expectancy of carriers of mutations in the human brain

PTEN dysfunction, caused by loss of lipid phosphatase activity or deletion, promotes pathologies, cancer, benign tumors, and neurodevelopmental disorders (NDDs). Despite efforts, exactly how the mutations trigger distinct phenotypic outcomes, cancer or NDD, has been puzzling. It has also been unclea...

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Detalles Bibliográficos
Autores principales: Jang, Hyunbum, Chen, Jiaye, Iakoucheva, Lilia M, Nussinov, Ruth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9900933/
https://www.ncbi.nlm.nih.gov/pubmed/36747841
http://dx.doi.org/10.1101/2023.01.26.525746

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9900933/
https://www.ncbi.nlm.nih.gov/pubmed/36747841
http://dx.doi.org/10.1101/2023.01.26.525746

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