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Autoinhibited kinesin-1 adopts a hierarchical folding pattern

Conventional kinesin-1 is the primary anterograde motor in cells for transporting cellular cargo. While there is a consensus that the C-terminal tail of kinesin-1 inhibits motility, the molecular architecture of a full-length autoinhibited kinesin-1 remains unknown. Here, we combine cross-linking ma...

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Detalles Bibliográficos
Autores principales: Tan, Zhenyu, Yue, Yang, da Veiga Leprevost, Felipe, Haynes, Sarah E., Basrur, Venkatesha, Nesvizhskii, Alexey I., Verhey, Kristen J., Cianfrocco, Michael A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9901034/
https://www.ncbi.nlm.nih.gov/pubmed/36747757
http://dx.doi.org/10.1101/2023.01.26.525761