Unusual crystal structures of MHC class I complexes reveal the elusive intermediate conformations explored during peptide editing in antigen presentation

Studies have suggested that MHC class I (MHC I) molecules fluctuate rapidly between conformational states as they sample peptides for potential ligands. To date, MHC I intermediates are largely uncharacterized experimentally and remain elusive. We present x-ray crystal structures of HLA-B8 loaded wi...

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Detalles Bibliográficos
Autores principales: Li, Lenong, Peng, Xubiao, Batliwala, Mansoor, Bouvier, Marlene
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9901037/
https://www.ncbi.nlm.nih.gov/pubmed/36747752
http://dx.doi.org/10.21203/rs.3.rs-2500847/v1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9901037/
https://www.ncbi.nlm.nih.gov/pubmed/36747752
http://dx.doi.org/10.21203/rs.3.rs-2500847/v1

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