Cargando…

Harnessing Transcriptomic Signals for Amyotrophic Lateral Sclerosis to Identify Novel Drugs and Enhance Risk Prediction

INTRODUCTION: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease. This study integrates the latest ALS genome-wide association study (GWAS) summary statistics with functional genomic annotations with the aim of providing mechanistic insights into ALS risk loci, inferring drug r...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pain, Oliver, Jones, Ashley, Al Khleifat, Ahmad, Agarwal, Devika, Hramyka, Dzmitry, Karoui, Hajer, Kubica, Jędrzej, Llewellyn, David J., Ranson, Janice M., Yao, Zhi, Iacoangeli, Alfredo, Al-Chalabi, Ammar
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9901068/ https://www.ncbi.nlm.nih.gov/pubmed/36747854 http://dx.doi.org/10.1101/2023.01.18.23284589

Ejemplares similares

Amyotrophic lateral sclerosis and cerebellum
por: Kabiljo, Renata, et al.
Publicado: (2022)

What causes amyotrophic lateral sclerosis?
por: Martin, Sarah, et al.
Publicado: (2017)

UK case control study of smoking and risk of amyotrophic lateral sclerosis
por: Opie-Martin, Sarah, et al.
Publicado: (2020)

A Knowledge-Based Machine Learning Approach to Gene Prioritisation in Amyotrophic Lateral Sclerosis
por: Bean, Daniel M., et al.
Publicado: (2020)

The impact of age on genetic testing decisions in amyotrophic lateral sclerosis
por: Mehta, Puja R, et al.
Publicado: (2022)

Younger age of onset in familial amyotrophic lateral sclerosis is a result of pathogenic gene variants, rather than ascertainment bias
por: Mehta, Puja R, et al.
Publicado: (2019)

Stage at which riluzole treatment prolongs survival in patients with amyotrophic lateral sclerosis: a retrospective analysis of data from a dose-ranging study
por: Fang, Ton, et al.
Publicado: (2018)

A HML6 endogenous retrovirus on chromosome 3 is upregulated in amyotrophic lateral sclerosis motor cortex
por: Jones, Ashley R., et al.
Publicado: (2021)

Author Correction: A HML6 endogenous retrovirus on chromosome 3 is upregulated in amyotrophic lateral sclerosis motor cortex
por: Jones, Ashley R., et al.
Publicado: (2022)

DNAscan2: a versatile, scalable, and user-friendly analysis pipeline for human next-generation sequencing data
por: Marriott, Heather, et al.
Publicado: (2023)

Frequency and methylation status of selected retrotransposition competent L1 loci in amyotrophic lateral sclerosis
por: Savage, Abigail L., et al.
Publicado: (2020)

A comprehensive analysis of rare genetic variation in amyotrophic lateral sclerosis in the UK
por: Morgan, Sarah, et al.
Publicado: (2017)

SCFD1 expression quantitative trait loci in amyotrophic lateral sclerosis are differentially expressed
por: Iacoangeli, Alfredo, et al.
Publicado: (2021)

Retrotransposons in the development and progression of amyotrophic lateral sclerosis
por: Savage, Abigail L, et al.
Publicado: (2019)

Quantifying Disease Progression in Amyotrophic Lateral Sclerosis
por: Simon, Neil G, et al.
Publicado: (2014)

An assessment of bioinformatics tools for the detection of human endogenous retroviral insertions in short-read genome sequencing data
por: Bowles, Harry, et al.
Publicado: (2023)

Clinical staging in amyotrophic lateral sclerosis: analysis of Edaravone Study 19
por: Al-Chalabi, Ammar, et al.
Publicado: (2021)

A polymorphic transcriptional regulatory domain in the amyotrophic lateral sclerosis risk gene CFAP410 correlates with differential isoform expression
por: Marshall, Jack N. G., et al.
Publicado: (2022)

Harnessing the potential of machine learning and artificial intelligence for dementia research
por: Ranson, Janice M., et al.
Publicado: (2023)

Infection of the Central Nervous System, Sepsis and Amyotrophic Lateral Sclerosis
por: Fang, Fang, et al.
Publicado: (2011)

VariantSurvival: a tool to identify genotype–treatment response
por: Krannich, Thomas, et al.
Publicado: (2023)

Development of a Smartphone App for a Genetics Website: The Amyotrophic Lateral Sclerosis Online Genetics Database (ALSoD)
por: Abel, Olubunmi, et al.
Publicado: (2013)

The risk to relatives of patients with sporadic amyotrophic lateral sclerosis
por: Hanby, Martha F., et al.
Publicado: (2011)

A standard operating procedure for King’s ALS clinical staging
por: Balendra, Rubika, et al.
Publicado: (2019)

A proposed staging system for amyotrophic lateral sclerosis
por: Roche, Jose C., et al.
Publicado: (2012)

RetroSnake: A modular pipeline to detect human endogenous retroviruses in genome sequencing data
por: Kabiljo, Renata, et al.
Publicado: (2022)

Evolution of white matter damage in amyotrophic lateral sclerosis
por: Gabel, Matt C., et al.
Publicado: (2020)

Harnessing cellular aging in human stem cell models of amyotrophic lateral sclerosis
por: Ziff, Oliver J., et al.
Publicado: (2018)

288 Harnessing the potential of transcriptional adaptation as a mechanism for Amyotrophic lateral sclerosis
por: Gomez, Adriana Morales, et al.
Publicado: (2023)

Improving clinical trial outcomes in amyotrophic lateral sclerosis
por: Kiernan, Matthew C., et al.
Publicado: (2020)

ALSgeneScanner: a pipeline for the analysis and interpretation of DNA sequencing data of ALS patients
por: Iacoangeli, Alfredo, et al.
Publicado: (2019)

Genetic correlation between amyotrophic lateral sclerosis and schizophrenia
por: McLaughlin, Russell L., et al.
Publicado: (2017)

An estimate of amyotrophic lateral sclerosis heritability using twin data
por: Al-Chalabi, A, et al.
Publicado: (2010)

The importance of offering early genetic testing in everyone with amyotrophic lateral sclerosis
por: Salmon, Kristiana, et al.
Publicado: (2022)

C9orf72 intermediate expansions of 24–30 repeats are associated with ALS
por: Iacoangeli, Alfredo, et al.
Publicado: (2019)

Structural variation analysis of 6,500 whole genome sequences in amyotrophic lateral sclerosis
por: Al Khleifat, Ahmad, et al.
Publicado: (2022)

Oral levosimendan in amyotrophic lateral sclerosis: a phase II multicentre, randomised, double-blind, placebo-controlled trial
por: Al-Chalabi, Ammar, et al.
Publicado: (2019)

Objectively Monitoring Amyotrophic Lateral Sclerosis Patient Symptoms During Clinical Trials With Sensors: Observational Study
por: Garcia-Gancedo, Luis, et al.
Publicado: (2019)

Telomere length analysis in amyotrophic lateral sclerosis using large-scale whole genome sequence data
por: Al Khleifat, Ahmad, et al.
Publicado: (2022)

Telomere length is greater in ALS than in controls: a whole genome sequencing study
por: Al Khleifat, Ahmad, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_oq23nanutcmavckdmrdbqlhq41