Molecular basis of RanGTP-activated nucleosome assembly with Histones H2A-H2B bound to Importin-9

Padavannil et al. 2019 show that Importin-9 (Imp9) transports Histones H2A-H2B from the cytoplasm to the nucleus using a non-canonical mechanism whereby binding of a GTP-bound Ran GTPase (RanGTP) fails to evict the H2A-H2B cargo. Instead, a stable complex forms, comprised of equimolar RanGTP, Imp9,...

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Detalles Bibliográficos
Autores principales: Shaffer, Joy M., Jiou, Jenny, Tripathi, Kiran, Olaluwoye, Oladimeji S., Fung, Ho Yee Joyce, Chook, Yuh Min, D’Arcy, Sheena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9901172/
https://www.ncbi.nlm.nih.gov/pubmed/36747879
http://dx.doi.org/10.1101/2023.01.27.525896

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9901172/
https://www.ncbi.nlm.nih.gov/pubmed/36747879
http://dx.doi.org/10.1101/2023.01.27.525896

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