Highly regioselective synthesis of lactams via cascade reaction of α,β-unsaturated ketones, ketoamides, and DBU as a catalyst

Herein, the aldol/Michael cascade reaction on the β,γ-positions of α,β-unsaturated ketones with ketoamides to construct bicyclic lactams via DBU catalysis has been developed. The substrates were well-tolerated with high regio- and diastereoselectivities in moderate to good yields (32 examples). The...

Descripción completa

Detalles Bibliográficos
Autores principales: Qin, Xin, Zhang, Jinhai, Wang, Zhan-Yong, Song, Yimei, Yang, Yixiao, Zhang, Wenhai, Liu, Hongxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9901288/
https://www.ncbi.nlm.nih.gov/pubmed/36760281
http://dx.doi.org/10.1039/d2ra07117g

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9901288/
https://www.ncbi.nlm.nih.gov/pubmed/36760281
http://dx.doi.org/10.1039/d2ra07117g

Ejemplares similares