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Highly regioselective synthesis of lactams via cascade reaction of α,β-unsaturated ketones, ketoamides, and DBU as a catalyst

Herein, the aldol/Michael cascade reaction on the β,γ-positions of α,β-unsaturated ketones with ketoamides to construct bicyclic lactams via DBU catalysis has been developed. The substrates were well-tolerated with high regio- and diastereoselectivities in moderate to good yields (32 examples). The...

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Detalles Bibliográficos
Autores principales:	Qin, Xin, Zhang, Jinhai, Wang, Zhan-Yong, Song, Yimei, Yang, Yixiao, Zhang, Wenhai, Liu, Hongxin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2023
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9901288/ https://www.ncbi.nlm.nih.gov/pubmed/36760281 http://dx.doi.org/10.1039/d2ra07117g

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