Early detection of exon 1 huntingtin aggregation in zQ175 brains by molecular and histological approaches

Huntingtin-lowering approaches that target huntingtin expression are a major focus for therapeutic intervention for Huntington’s disease. When the cytosine, adenine and guanine repeat is expanded, the huntingtin pre-mRNA is alternatively processed to generate the full-length huntingtin and HTT1a tra...

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Detalles Bibliográficos
Autores principales: Smith, Edward J, Sathasivam, Kirupa, Landles, Christian, Osborne, Georgina F, Mason, Michael A, Gomez-Paredes, Casandra, Taxy, Bridget A, Milton, Rebecca E, Ast, Anne, Schindler, Franziska, Zhang, Chuangchuang, Duan, Wenzhen, Wanker, Erich E, Bates, Gillian P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9901570/
https://www.ncbi.nlm.nih.gov/pubmed/36756307
http://dx.doi.org/10.1093/braincomms/fcad010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9901570/
https://www.ncbi.nlm.nih.gov/pubmed/36756307
http://dx.doi.org/10.1093/braincomms/fcad010

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